میزان میکروترومبوز در آلوئولار کپیلاری در بیماران کووید۱۹ ، نه برابر بیشتر از آنفولانزا بوده و میزان عروق جدید ساخته شده حدود ۲.۷ برابر بوده در بیماران کووید۱۹ در مقایسه با بیماران آنفولانزایی.
مکانیسم اصلی ساخت عروق تازه ، intussusceptive angiogenesis بوده است.
توضیح intussusceptive angiogenesis:
Intussusceptive angiogenesis also known as splitting angiogenesis, is a type of angiogenesis, the process whereby a new blood vessel is created. By intussusception a new blood vessel is created by splitting of an existing blood vessel in two.
Alveolar capillary microthrombi were 9 times as prevalent in patients with Covid-19 as in patients with influenza (P<0.001). In lungs from patients with Covid-19, the amount of new vessel growth — predominantly through a mechanism of intussusceptive angiogenesis — was 2.7 times as high as that in the lungs from patients with influenza (P<0.001).
Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMoa2015432?query=C19&cid=DM92284_NEJM_Registered_Users_and_InActive&bid=201122076